Multi-Functional Core-Shell Nanofibers for Wound Healing

Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different phases. Compared monoaxial nanofibers, core-shell can control the drug release profile easier, providing sustainable effective healing. However, it is challenging produce structured with a high production rate low energy consumption. Co-axial centrifugal spinning an alternative method address above limitations effectively. In this study, co-axial device was designed assembled controlling of ibuprofen hEGF in inflammation proliferation phases during process. were confirmed by TEM. This work demonstrated that productivity process materials 3D environment mimicking natural tissue scaffold, specific loaded into layers improve efficiency promote